The Digital Research Alliance of Canada (formerly Compute Canada) manages national HPC clusters running customized Slurm workload manager configurations and contributes open-source tooling for scientific computing. Their open-source stack powers university research across the country.

Open edX is the open-source platform powering edX and hundreds of university MOOC programs. Canadian institutions including University of Toronto, UBC, and McGill have contributed significantly to its development and deploy it for online learning.

CANARIE manages the Canadian Access Federation (CAF), which provides open-source Shibboleth identity federation infrastructure enabling single sign-on for over 300 Canadian universities, colleges, and research institutions. Their open tools and configuration guides are publicly available.

OpenMRS is an open-source medical record system used in developing countries. The University of Toronto and affiliated Canadian researchers are among the primary contributors to its core platform and modules, helping deliver healthcare technology globally.

CanAssist at the University of Victoria develops open-source assistive technology tools and custom software for people with disabilities. Their free toolbox includes communication aids, alternative input interfaces, and educational software freely available to Canadians.

SageMath is a free open-source mathematics software system. The Pacific Institute for the Mathematical Sciences (PIMS), a consortium of Canadian universities, provides infrastructure and hosting for SageMath and has been a key institutional backer of open mathematical software in Canada.

OpenStax provides free, peer-reviewed open-source textbooks. Toronto Metropolitan University (TMU) and several other Canadian institutions are active contributors to the platform's open educational resources and have helped adapt content for Canadian curricula.

OSCAR EMR (Open Source Clinical Application Resource) is a Canadian-developed open-source electronic medical records system used by thousands of primary care physicians across Canada. Developed at McMaster University, it supports bilingual interfaces and Canadian-specific clinical workflows including OHIP billing.